Sinha Lab Data Explorer

Integrated Adult and Foetal Hearts

Adult and Foetal hearts were integrated using R Seurat's reciprocal principal component analysis (RPCA) pipeline. This dataset contains single-cell RNA sequencing from 7 foetal hearts between the ages of 8 and 11 weeks post-conception dissected into either base or apex. Foetal data were combined with similar data from multiple regions from 6 adult hearts, including single nuclei (Heart Cell Atlas). This dataset contains a sub-sampled and balanced composition of cell types as described in the materials and methods of the article. Raw data is available from GEO using the accession ID GSE216019.

Associated papers

Knight-Schrijver, V.R., Davaapil, H., Bayraktar, S. et al. A single-cell comparison of adult and fetal human epicardium defines the age-associated changes in epicardial activity. Nat Cardiovasc Res 1, 1215-1229 (2022). https://doi.org/10.1038/s44161-022-00183-w