Publications

Recent and selected publications are listed below.

Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration.Bargehr J, Ong LP, Colzani M, Davaapil H, Hofsteen P, Bhandari S, Gambardella L, Le Novère N, Iyer D, Sampaziotis F, Weinberger F, Bertero A, Leonard A, Bernard WG, Martinson A, Figg N, Regnier M, Bennett MR, Murry CE and Sinha S. Nat Biotechnol.2019 Aug;37(8):895-906.

A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration. Serrano F, Bernard WG, Granata A, Iyer D, Steventon B, Kim M, Vallier L, Gambardella L, Sinha S. Stem Cells Dev. 2019 Jan 15;28(2):81-100.

Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF. Malcor JD, Juskaite V, Gavriilidou D, Hunter EJ, Davidenko N, Hamaia S, Sinha S, Cameron RE, Best SM, Leitinger B, Farndale RW. Biomaterials. 2018 Nov;182:21-34.

Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by Induced Pluripotent Stem Cell Modeling. Kiskin FN, Chang CH, Huang CJZ, Kwieder B, Cheung C, Dunmore BJ, Serrano F, Sinha S, Morrell NW, Rana AA. Am J Respir. Crit Care Med. 2018 Jul 15;198(2):271-275.

New models to study vascular mural cell embryonic origin: implications in vascular diseases. Sinha S, Santoro MM. Cardiovasc Res. 2018 Mar 15;114(4):481-491.

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL 3rd, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander GJ, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, Melum E, Markaki AE, Saeb-Parsy K, Vallier L. Nat Med. 2017 Aug;23(8):954-963.

Exposure of Induced Pluripotent Stem Cell-Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell-Like Phenotypes. Collado MS, Cole BK, Figler RA, Lawson M, Manka D, Simmers MB, Hoang S, Serrano F, Blackman BR, Sinha S, Wamhoff BR. Stem Cells Transl Med. 2017 Aug;6(8):1673-1683. Stem Cells Transl Med. 2017 Aug;6(8):1673-1683.

Human Stem Cell-Derived Endothelial-Hepatic Platform for Efficacy Testing of Vascular-Protective Metabolites from Nutraceuticals. Narmada BC, Goh YT, Li H, Sinha S, Yu H, Cheung C. Stem Cells Transl Med. 2017 Mar;6(3):851-863.

An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death. Granata A, Serrano F, Bernard WG, McNamara M, Low L, Sastry P, Sinha SNat Genet. 2017 Jan;49(1):97-109.

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs. Bertero A, Pawlowski M, Ortmann D, Snijders K, Yiangou L, Cardoso de Brito M, Brown S, Bernard WG, Cooper JD, Giacomelli E, Gambardella L, Hannan NR, Iyer D, Sampaziotis F, Serrano F, Zonneveld MC, Sinha S, Kotter M, Vallier L. Development. 2016 Dec 1;143(23):4405-4418.

Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation. Bargehr J, Low L, Cheung C, Bernard WG, Iyer D, Bennett MR, Gambardella L, Sinha SStem Cells Transl Med. 2016 Jul;5(7):946-59.

Vascular Smooth Muscle Cells in Atherosclerosis. Bennett MR, Sinha S, Owens GK. Circ Res. 2016 Feb 19;118(4):692-702.

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells. Iyer D, Gambardella L, Bernard WG, Serrano F, Mascetti VL, Pedersen RA, Talasila A, Sinha S. Development. 2015 Apr 15;142(8):1528-41.

Myocardin regulates vascular smooth muscle cell inflammatory activation and disease. Ackers-Johnson M, Talasila A, Sage AP, Long X, Bot I, Morrell NW, Bennett MR, Miano JM, Sinha SArterioscler Thromb Vasc Biol. 2015 Apr;35(4):817-28

Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3. Granata A, Bernard WG, Zhao N, Mccafferty J, Lilly B, Sinha S. Stem Cells Dev. 2015 Apr 1;24(7):846-56.

Directed differentiation of embryonic origin-specific vascular smooth muscle subtypes from human pluripotent stem cells. Cheung C, Bernardo AS, Pedersen RA, Sinha S. Nat Protoc. 2014 Apr;9(4):929-38.

Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application.  Sinha S, Iyer D, Granata A. Cell Mol Life Sci. 2014 Jun;71(12):2271-88.

Myocardin Regulates Vascular Response to Injury Through miR-24/-29a and Platelet-Derived Growth Factor Receptor-β. Talasila A, Yu H, Ackers-Johnson M, Bot M, van Berkel T, Bennett MR, Bot I, Sinha S. Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2355-65.

Embryological-origin-dependent differences in homeobox expression in adult aorta: role in regional phenotypic variability and regulation of NF-κB activity. Trigueros-Motos L, González-Granado JM, Cheung C, Fernández P, Sánchez-Cabo F, Dopazo A, Sinha S, Andrés V. Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1248-56.

Vascular disease in a dish: all the right ingredients? Sinha SCirculation. 2012 Oct 2;126(14):1676-7.

Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility. Cheung C, Bernardo AS, Trotter MW, Pedersen RA, Sinha SNat Biotechnol. 2012 Jan 15;30(2):165-73.

Myocardin overexpression is sufficient for promoting the development of a mature smooth muscle cell-like phenotype from human embryonic stem cells. Raphel L, Talasila A, Cheung C, Sinha SPLoS One. 2012;7(8):e44052.

Human embryonic stem cell-derived vascular smooth muscle cells in therapeutic neovascularisation. Cheung C, Sinha SJ Mol Cell Cardiol. 2011 Nov;51(5):651-64.